S3131

Sulindac sulfide

≥98% (HPLC), solid

• 동의어(들): (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
• 실험식(Hill 표기법): C₂₀H₁₇FO₂S
• CAS Number: 32004-67-4
• Molecular Weight: 340.41
• EC Number: 250-892-2
• MDL number: MFCD00869764
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24899543
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: yellow
• solubility: DMSO: ≥22 mg/mL
• SMILES string: [H]\C(c1ccc(SC)cc1)=C2/C(C)=C(CC(O)=O)c3cc(F)ccc23
• InChI: 1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
• InChI key: LFWHFZJPXXOYNR-MFOYZWKCSA-N

설명

애플리케이션

Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.

생화학적/생리학적 작용

Sulindac sulfide is a non-steroidal anti-inflammatory compound with a preference for COX-1; it is an inhibitor of Ras activation of Raf-1. It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac. It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells and reduces tumor burden in adenomatous polyposis patients.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H317,H334,H361
• 예방조치 성명서: P201 - P280 - P301 + P312 + P330 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges