S3445

SM-19712 hydrate

≥98% (HPLC)

• 동의어(들): 4-Chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl]benzenesulfonamide sodium salt hydrate
• 실험식(Hill 표기법): C₁₈H₁₃ClN₅NaO₃S · xH₂O
• CAS Number: 194542-56-8
• Molecular Weight: 437.84 (anhydrous basis)
• MDL number: MFCD06798351
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824532
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: off-white to light brown
• solubility: DMSO: ≥20 mg/mL; H₂O: ≥20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: ClC1=CC=C(S(N(C(NC2=C(C#N)C(C)=NN2C3=CC=CC=C3)=O)[Na])(=O)=O)C=C1
• InChI: 1S/C12H10ClN5O3S.Na.H2O/c1-7-10(6-14)11(17-16-7)15-12(19)18-22(20,21)9-4-2-8(13)3-5-9;;/h2-5H,1H3,(H3,15,16,17,18,19);;1H2/q;+1;/p-1
• InChI key: HLHPDQXMLDUDQV-UHFFFAOYSA-M

설명

애플리케이션

SM-19712 hydrate was used in studies to determine the effectiveness of ECE inhibition as a treatment option for Alzheimer′s disease.

생화학적/생리학적 작용

Nonpeptide, potent and selective endothelin converting enzyme inhibitor.

SM-19712 a sulfonylureid-pyrazole derivative is a potent and selective inhibitor of endothelin converting enzyme (ECE). It attenuates the effects of ischemic acute renal failure and reduces the inflammation, tissue injury and vasoconstriction induced by dextran sodium sulfate in mouse colon.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves