S3567

SB 415286

≥98% (HPLC)

• 동의어(들): 3-[(3-Chloro-4-hydroxyphenyl)­amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione
• 실험식(Hill 표기법): C₁₆H₁₀N₃O₅Cl
• CAS Number: 264218-23-7
• Molecular Weight: 359.72
• MDL number: MFCD04039789
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278412
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 색상: yellow to orange
• solubility: DMSO: 5 mg/mL, clear; H₂O: insoluble
• 주관자: GlaxoSmithKline
• 저장 온도: −20°C
• SMILES string: Oc1ccc(NC2=C(C(=O)NC2=O)c3ccccc3[N+]([O-])=O)cc1Cl
• InChI: 1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
• InChI key: PQCXVIPXISBFPN-UHFFFAOYSA-N
• 유전자 정보: human ... GSK3A(2931), GSK3B(2932)

설명

애플리케이션

SB 415286 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation.

생화학적/생리학적 작용

Glycogen synthase kinase-3 (GSK-3) inhibitor.

SB 415286 is a small molecule inhibitor of GSK-3 in muscle and fat cells. SB 415286 induces activation of glycogen synthase and regulates the transport glucose. SB 415286 reduces the systemic inflammation induced by endotoxic shock in rat model of acute colitis. It increases the axonal growth and promotes the recovery of injured adult CNS neurons. SB 415289 is implicated in inducing chromosome instability when used as therapeutic agents.

특징 및 장점

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

법적 정보

Sold for research purposes under agreement from GlaxoSmithKline.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves