S7071

SD-208

≥98% (HPLC), powder

• 동의어(들): 2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine
• 실험식(Hill 표기법): C₁₇H₁₀ClFN₆
• CAS Number: 627536-09-8
• Molecular Weight: 352.75
• MDL number: MFCD11519969
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24899731
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: off-white to tan
• solubility: DMSO: >5 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2
• InChI: 1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
• InChI key: BERLXWPRSBJFHO-UHFFFAOYSA-N

설명

애플리케이션

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.²

생화학적/생리학적 작용

SD-208 is TGF-βR I kinase inhibitor with IC₅₀ =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

SD-208 is a novel transforming growth factor beta receptor I (TGF-βR I) kinase inhibitor. SD-208 inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.¹

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves