S8809

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse

~1 mg/mL, clone K58/35, purified immunoglobulin

• 동의어(들): Sodium Channel Antibody
• MDL number: MFCD02097413
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: K58/35, monoclonal
• 종 반응성: mammals
• 농도: ~1 mg/mL
• 기술: immunohistochemistry (frozen sections): suitable; indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons; western blot: 1 μg/mL using crude brain membrane prep (rat)
• 동형: IgG1
• UniProt 수납 번호: P35498
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN8A(6334), SCN9A(6335) ; mouse ... Scn10a(20264), Scn11a(24046), Scn1a(20265), Scn3a(20269), Scn4a(110880), Scn5a(20271), Scn8a(20273), Scn9a(20274) ; rat ... Scn10a(29571), Scn11a(29701), Scn1a(81574), Scn3a(497770), Scn4a(25722), Scn5a(25665), Scn8a(29710), Scn9a(78956)

설명

일반 설명

Voltage-gated sodium channels/VGSCs (Nav) are transmembrane proteins that are initiated by the depolarization of the membrane. They are heteromultimers with large pore-forming α-subunits and smaller β-subunits.

특이성

The sequence recognized by this clone is identical in all known vertebrate Na⁺ channels. In cultured hippocampal neurons, the antibody specifically stains the axon initial segment. In sciatic and optic nerves, it stains the nodes of Ranvier.

면역원

synthetic peptide CTEEQKKYYNAMKKLGSKK from the intracellular III-IV loop of Na⁺ channels

애플리케이션

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse has been used in:

• immunohistochemistry(1:50)
• immunostaining (1:200)
• immunofluorescence
• immunocytochemistry (1:100)

생화학적/생리학적 작용

Voltage-gated sodium channels/VGSCs (Nav) participates in nociceptive transmission. They play a key role in regulating the exchange between the extracellular and intracellular spaces. VGSCs are crucial for the initiation and firing of action potentials. They participate in neuronal excitability. Hence mutations in the VGSC genes results in several epileptic disorders.

물리적 형태

Solution in 10 mM Tris, pH 7.5, containing 0.1 m NaCl, 30% glycerol, and 15 mM sodium azide.

법적 정보

Sold under exclusive license from SUNY Stony Brook.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.