SAB1300081

Anti-LRP1 (C-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 동의어(들): Anti-α-2-macroglobulin receptor, Anti-A2MR, Anti-Apolipoprotein E receptor, Anti-LRP, Anti-Low-density lipoprotein receptor-related protein 1
• UNSPSC 코드: 12352203
• NACRES: NA.43

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: IgG fraction of antiserum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 종 반응성: human
• 기술: immunohistochemistry: 1:50-1:100; indirect ELISA: 1:1000
• NCBI 수납 번호: NP_002323
• UniProt 수납 번호: Q07954
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... LRP1(4035)

설명

일반 설명

LRP1 (low density receptor protein 1) gene codes for a protein belonging to LDL receptor family. Lrp1 is known to be the largest mammalian endocytic receptor. The encoded protein is cysteine-rich and it is highly glycosylated. It is predominantly expressed in vascular smooth muscle cells, neurons, astrocytes, macrophages, hepatocytes, fibroblasts and malignant cells. The LDLRs (low-density lipoprotein receptors) have five domains namely repeated cysteine-rich regions of ligand-binding type and epidermal growth factor receptor-like repeats, YWTD (tyrosin, typrtophan, Threonine, aspartic) domains, a transmembrane domain, and a cytoplasmic tail that holds about three NPXY (asparagine-proline-X-tyrosine) motifs.

면역원

LRP1 (4520-4554)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP1.

생화학적/생리학적 작용

LRP1 functions as a scavenger by internalizing several plasma components and also serves as a signaling molecule. Lrp1 is responsible for the transport of β-amyloid (Aβ) across the blood brain barrier, thereby contributing to the pathogenesis of Alzheimer′s disease. Lrp1 is normally associated with the cell membrane, but proteolytic cleavage of the cell results in its soluble form. Therefore, it loses its ability to endocytose and transport ligands. LRP1 is associated with a number of signaling pathways, such as mitogen-activated protein kinase (MAPK), serine/threonine protein kinase (AKT), insulin receptor (IR), extracellular signal-regulated kinase (ERK), and c-jun N-terminal kinase (JNK) pathways.

물리적 형태

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable