SAB4500090

Anti-ADARB1 antibody produced in rabbit

affinity isolated antibody

• 동의어(들): RNA-editing deaminase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase
• MDL number: MFCD02686608
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen 80 kDa
• 종 반응성: rat, mouse, human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:20000; western blot: 1:500-1:1000
• NCBI 수납 번호: P78563
• UniProt 수납 번호: P78563
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ADARB1(104)

설명

일반 설명

Adenosine deaminase, RNA specific B1 (ADARB1) is encoded by the gene mapped to human chromosome 21q22.3, a region associated with familial bipolar disorder. ADARB1 is characterized with two double-stranded RNA-binding domains and a deaminase domain involved in editing action.

면역원

The antiserum was produced against synthesized peptide derived from human ADARB1.

Immunogen Range: 481-530

생화학적/생리학적 작용

Adenosine deaminase, RNA specific B1 (ADARB1) enzyme plays a vital role in editing pre-mRNA of glutamate receptor B subunit. Combined effect of ADARB1 and HTR2C (5-Hydroxytryptamine Receptor 2C) variants contribute to the suicide attempt (SA) vulnerability in psychiatric patients. ADARB1 is a candidate gene for neurological diseases, such as bipolar affective disorder and epilepsy. Decrease in the activity of ADAR2 enzyme results in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated death of motor neurons in mice. ADARB1 enzyme is expressed consistently in carcinomas and sarcomas, and it is upregulated in lymphomas and seminomas when compared to normal tissues.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable