SAB5200049

Monoclonal Anti-GABRB3 antibody produced in mouse

clone S87-25, 1 mg/mL, purified immunoglobulin

• 동의어(들): Anti-GABA(A) receptor subunit beta3, Anti-GABAAR Beta3, S87-25, Anti-Gabrb3
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: S87-25, monoclonal
• 양식: buffered aqueous glycerol solution
• 분자량: antigen predicted mol wt 55 kDa
• 종 반응성: human, mouse, rat
• 농도: 1 mg/mL
• 기술: immunocytochemistry: suitable; western blot: suitable
• 동형: IgG1
• NCBI 수납 번호: NP_032097.1
• UniProt 수납 번호: P28472
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... Gabrb3(14402)

설명

일반 설명

The γ-aminobutyric acid type A receptor β3 subunit (GABRB3) gene with nine exons spanning 250kb, is mapped to human chromosome 15q12, a hot region of genomic rearrangements. The gene codes for β3 subunit of GABAA receptor, which belongs to the GABA (γ-aminobutyric acid) receptor gene family.

특이성

Detects ~55 kDa. No cross-reactivity against GABA-A-R-Beta 2 or –Beta1.

면역원

Fusion protein amino acids 370-433 of mouse GABA-A_r Beta3, Accession Number AAB60502.

생화학적/생리학적 작용

γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC). Alteration in the gene results in increased tactile sensitivity, or hypersensitivity. Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia. GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P).

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable