SAB5300028

Monoclonal Anti-RAB10 antibody produced in mouse

clone 4E2, ascites fluid

• 동의어(들): RAB10
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: 4E2, monoclonal
• 분자량: 22.5 kDa
• 종 반응성: mouse, human
• 기술: direct ELISA: 1:10,000; indirect immunofluorescence: 1:200-1:1,000; western blot: 1:500-1:2,000
• 동형: IgG1
• NCBI 수납 번호: NM_016131
• UniProt 수납 번호: P61026
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... Rab10(10890)

설명

일반 설명

Rab10, a small monomeric Ras-related GTP-binding protein, is a member of the rat sarcoma (RAS) family. RAB10 gene has GTP and GDP binding domains. RAB10 gene is located on human chromosome 2p23.3.

면역원

Purified recombinant fragment of human Rab10 expressed in E.coli.
Mouse monoclonal antibody raised against Rab10

애플리케이션

Monoclonal Anti-RAB10 antibody produced in mouse has been used in western blotting (1:1000) and immunocytochemistry (1:1000).

생화학적/생리학적 작용

RAB10 is involved in intracellular vesicle trafficking. It is important for insulin-stimulated glucose transporter type 4 (GLUT4) translocation in adipocytes, the secretion of the basement membrane, and endoplasmic reticulum development and maintenance (ER). It controls toll-like receptor 4 (TLR4) trafficking, which is crucial for innate immune responses. Rab10 gene knockdown reduces the production of Aβ and higher expression of Rab10 enhances amyloid β protein (Aβ) production in cultured neuroblastoma cells. Phosphorylation of Rab10 could be the cause of vesicle trafficking abnormalities that lead to neurodegeneration in Alzheimer′s disease. Overexpression of RAB10 is observed in hepatocellular carcinoma (HCC).

물리적 형태

Ascitic fluid containing 0.03% sodium azide.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable