SAB6010054

Anti-phospho-PAK1/PAK2/PAK3 (S144+S141+S139) antibody, clone 3H12, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• 동의어(들): Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3
• UNSPSC 코드: 12352203

속성

• 재조합: expressed in HEK 293 F cells
• Quality Level: 100
• 결합: unconjugated
• 항체 생산 유형: primary antibodies
• 클론: 3H12, recombinant monoclonal
• 양식: liquid
• 분자량: 150 kDa
• 정제법: affinity chromatography
• 종 반응성: human
• 농도: 0.53mg/ml
• 기술: ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• 동형: IgG
• UniProt 수납 번호: O75914/Q13153/Q13177
• 배송 상태: wet ice
• 저장 온도: -10 to -25°C
• 타겟 번역 후 변형: phosphorylation (pSer144+pSer141+pSer139)

설명

일반 설명

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

면역원

A synthesized peptide derived from human Phospho-PAK1/PAK2/PAK3 (S144+S141+S139)

서열

YM-pS-FT

물리적 형태

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

저장 및 안정성

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable