SBR00011

Clarithromycin, Ready Made Solution

50 mg/mL in DMSO

• 동의어(들): 6-O-methyl erythromycin
• 실험식(Hill 표기법): C₃₈H₆₉NO₁₃
• CAS Number: 81103-11-9
• Molecular Weight: 747.95
• MDL number: MFCD00865140
• UNSPSC 코드: 51102829
• PubChem Substance ID: 329824644
• NACRES: NA.85

속성

• 설명: Ready Made Solution
• Quality Level: 200
• 양식: liquid
• 저장 조건: dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
• 농도: 50 mg/mL in DMSO
• 색상: colorless to faint yellow
• 항생제 활성 스펙트럼: Gram-positive bacteria
• 동작 모드: protein synthesis | interferes
• 저장 온도: −20°C
• SMILES string: N([C@@H]1[C@H]([C@@H](O[C@@H](C1)C)O[C@@H]2[C@H]([C@@H]([C@H](C(=O)O[C@@H]([C@]([C@@H]([C@H](C(=O)[C@@H](C[C@]2(OC)C)C)C)O)(O)C)CC)C)O[C@@H]3O[C@H]([C@@H]([C@@](C3)(OC)C)O)C)C)O)(C)C
• InChI: 1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
• InChI key: AGOYDEPGAOXOCK-KCBOHYOISA-N

설명

일반 설명

Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.

애플리케이션

Clarithromycin may be used for-

• the study of the effects of clarithromycin on rate-dependent changes in QT, T_p-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations
• the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays
• the study of the synergism of NAB741 with clarithromycin in microtiter plates.

생화학적/생리학적 작용

Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation.

포장

2ML

저장 및 안정성

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 188.6 °F
• Flash Point (°C): 87 °C