SMB00579

Tacalcitol

≥99% (HPLC)

• 동의어(들): (1α,3β,5Z,7E,24R)-9,10-secocholesta-5,7,10(19)-triene-1,3,24-triol, 1α,24R-dihydroxycholecalciferol, 1α,24R-dihydroxyvitamin D₃
• 실험식(Hill 표기법): C₂₇H₄₄O₃
• CAS Number: 57333-96-7
• Molecular Weight: 416.64
• MDL number: MFCD00866623
• UNSPSC 코드: 12352205
• PubChem Substance ID: 329825068
• NACRES: NA.79

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥99% (HPLC)
• 양식: powder
• 기술: HPLC: suitable
• 색상: white to off-white
• 저장 온도: −20°C
• SMILES string: C[C@]1(CCC/2)[C@](CC[C@]1([H])[C@H](C)CC[C@@H](O)C(C)C)([H])C2=C\C=C3C[C@@H](O)C[C@H](O)C\3=C
• InChI: 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
• InChI key: BJYLYJCXYAMOFT-RSFVBTMBSA-N

설명

일반 설명

Tacalcitol is a synthetic vitamin D₃ analog. It is a vitamin D3 derivative, also known as 1α,24-dihydroxyvitamin D3.

생화학적/생리학적 작용

Tacalcitol is widely used in the treatment of dermatosis due to its ability to inhibit keratinocyte proliferation and induce cell differentiation. It also has anti-inflammatory activity and has been shown to reduce cutaneous inflammation via suppression of leukocyte infiltration in skin. Tacalcitol is topically used for the treatment of psoriasis and has also been found to be effective in the treatment of acquired perforating collagenosis (APC), a rare perforating dermatosis. Studies suggest that this compound has potential for the treatment of the hereditary disorder Hailey-Hailey Disease.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300
• 예방조치 성명서: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 1 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable