SML0207

SB 328437

≥98% (HPLC)

• 동의어(들): L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester
• 실험식(Hill 표기법): C₂₁H₁₈N₂O₅
• CAS Number: 247580-43-4
• Molecular Weight: 378.38
• MDL number: MFCD16618397
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329825229
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to tan
• solubility: DMSO: ≥10 mg/mL
• 주관자: GlaxoSmithKline
• 저장 온도: 2-8°C
• SMILES string: COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23
• InChI: 1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
• InChI key: VMFGCGRAIBLAFY-IBGZPJMESA-N

설명

애플리케이션

SB 328437 may be used to study CCR3-mediated cell signaling in asthma models.

생화학적/생리학적 작용

SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.

SB-328437 is a CCR3 Antagonist.

SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.

특징 및 장점

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable