SML0256

2OHOA

≥98% (HPLC)

• 동의어(들): (9Z)-2-Hydroxy-9-octadecenoic acid; cis-2-Hydroxy-9-octadecenoic acid, 2-Hydroxy Oleic Acid, Minerval
• 실험식(Hill 표기법): C₁₈H₃₄O₃
• CAS Number: 56472-29-8
• Molecular Weight: 298.46
• MDL number: MFCD07778553
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825264
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 저장 조건: protect from light
• 색상: white to tan
• solubility: DMSO: >20 mg/mL
• 저장 온도: room temp
• SMILES string: CCCCCCCC\C=C/CCCCCCC(O)C(O)=O
• InChI: 1S/C18H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h9-10,17,19H,2-8,11-16H2,1H3,(H,20,21)/b10-9-
• InChI key: JBSOOFITVPOOSY-KTKRTIGZSA-N

설명

애플리케이션

2OHOA has been used as:

• a modulator of the sphingolipid and glycerophospholipid pathway to study its effects on myelination in mice Charcot–Marie–Tooth type 1A (CMT1A) myelinopathy and myelinating dorsal root ganglia cultures
• in biophysical studies to study its effects on artificial membranes
• to study its interactions with major membrane lipid films

생화학적/생리학적 작용

2-Hydroxy oleic acid (2OHOA) is a derivative of oleic acid. It plays a role in membrane organization, alterations in membrane fluidity, an increase of the tendency to form non-lamellar structures, and remodeling of microdomains by interacting with the lipids in membranes of pathological cells.

2OHOA induces cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2OHOA increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.

2OHOA is an antitumor agent; sphingomyelin synthase activator.

안전성 정보

• 픽토그램: GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H318
• 예방조치 성명서: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable