SML0273

VAS2870

≥97% (HPLC)

• 동의어(들): 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine, VAS 2870, VAS-2870
• 실험식(Hill 표기법): C₁₈H₁₂N₆OS
• CAS Number: 722456-31-7
• Molecular Weight: 360.39
• MDL number: MFCD03407188
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825281
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: ≥5 mg/mL
• 저장 온도: room temp
• SMILES string: C(c1ccccc1)n2nnc3c(Sc4nc5ccccc5o4)ncnc23
• InChI: 1S/C18H12N6OS/c1-2-6-12(7-3-1)10-24-16-15(22-23-24)17(20-11-19-16)26-18-21-13-8-4-5-9-14(13)25-18/h1-9,11H,10H2
• InChI key: HZSOKHVVANONPV-UHFFFAOYSA-N

설명

애플리케이션

VAS2870 has been used as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor:

• to study the importance of NOX-derived reactive oxygen species in cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly
• to study the function of Nox2 and Nox4 in lipopolysaccharide (LPS)-induced intestinal injury in high-fat diet (HFD) fed mice
• to reduce the reactive oxygen species level and study its influence on inhibiting the induction of trained innate immunity in monocytes

생화학적/생리학적 작용

In addition to NOX4 inhibition, VAS2870 is also known to supress the reactive oxygen species (ROS) production in several cell types. It effectively impairs cell growth and increases apoptosis induced by transforming growth factor β (TGF-β) in liver cancer cells. Thus, inhibition of NOX enzymes by VAS2870 may be considered as a potential therapeutic strategy for liver cancer.

VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC.

VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable