SML0384

Eicosapentaenoyl ethanolamide

5 mg/mL in absolute ethanol, ≥98% (HPLC)

• 동의어(들): (5Z,8Z,11Z,14Z,17Z)-N-(2-Hydroxyethyl)-5,8,11,14,17-eicosapentaenamide, EPEA
• 실험식(Hill 표기법): C₂₂H₃₅NO₂
• CAS Number: 109001-03-8
• Molecular Weight: 345.52
• MDL number: MFCD22416528
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329825384
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solution
• 약물 제어: regulated under CDSA - not available from Sigma-Aldrich Canada
• 저장 조건: protect from light; under inert gas
• 농도: 5 mg/mL in absolute ethanol
• 색상: light yellow
• 저장 온도: −20°C
• SMILES string: CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO
• InChI: 1S/C22H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h3-4,6-7,9-10,12-13,15-16,24H,2,5,8,11,14,17-21H2,1H3,(H,23,25)/b4-3-,7-6-,10-9-,13-12-,16-15-
• InChI key: OVKKNJPJQKTXIT-JLNKQSITSA-N

설명

생화학적/생리학적 작용

Eicosapentaenoyl ethanolamide (EPEA) is a lipid mediator that has been found to suppress lifespan extension resulting from dietary restriction in C. elegans and also to have antiproliferative and anti-inflammatory actions. In C. elegans, it is believed to act as a metabolic signal that couples nutrient availability with growth and lifespan. EPEA is a member of the N-acylethanolamines (NAEs), lipid-derived signaling molecules that include the mammalian endocannabinoid arachidonoyl ethanolamide (AEA). In mammals, NAEs are believed to act primarily through cannabinoid receptors, although they can also interact with a variety of other targets, and EPEA has been shown to act as a CB1 and CB2 receptor agonist. However, C. elegans does not possess clear orthologues of the mammalian cannabinoid receptors which suggests that there are unidentified NAE receptors in nematodes that are possibly conserved mediators of NAE signaling.

Eicosapentaenoyl ethanolamide (EPEA) is a lipid mediator; suppresses lifespan extension; anti proliferative and anti-inflammatory.

기타 정보

Light and air sensitive; store in a freezer.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable