SML0440

Spautin-1

≥98% (HPLC)

• 동의어(들): 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine, C43
• 실험식(Hill 표기법): C₁₅H₁₁F₂N₃
• CAS Number: 1262888-28-7
• Molecular Weight: 271.26
• MDL number: MFCD16962292
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824722
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 15 mg/mL (clear solution)
• 저장 온도: 2-8°C
• SMILES string: FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
• InChI: 1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
• InChI key: AWIVHRPYFSSVOG-UHFFFAOYSA-N

설명

애플리케이션

Spautin-1 has been used as an autophagy inhibitor:

• to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model
• to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin
• to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay

생화학적/생리학적 작용

Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.

Spautin-1 is an inhibitor of autophagy.

Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H318
• 예방조치 성명서: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable