SML0472

4-IPP

≥97% (HPLC)

• 동의어(들): 4-Iodo-6-phenylpyrimidine
• 실험식(Hill 표기법): C₁₀H₇IN₂
• CAS Number: 41270-96-6
• Molecular Weight: 282.08
• MDL number: MFCD00234609
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825428
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 10 mg/mL (clear solution, warmed)
• 저장 온도: −20°C
• SMILES string: Ic1cc(ncn1)-c2ccccc2
• InChI: 1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
• InChI key: ZTCJXHNJVLUUMR-UHFFFAOYSA-N

설명

애플리케이션

4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.

생화학적/생리학적 작용

4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist that covalently modifies MIF N-terminal proline.

4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist.

4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3