SML0503

9(S)-HODE

≥98% (HPLC)

• 동의어(들): 9S-Hydroxy-10E,12Z-octadecadienoic acid
• 실험식(Hill 표기법): C₁₈H₃₂O₃
• CAS Number: 73543-67-6
• Molecular Weight: 296.44
• EC Number: 200-578-6
• MDL number: MFCD00065831
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329825451
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solution
• 농도: 1 mg/mL in ethanol
• 색상: colorless to light yellow
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: CCCCC/C=C\C=C\[C@@H](O)CCCCCCCC(O)=O
• InChI: 1S/C18H32O3/c1-2-3-4-5-6-8-11-14-17(19)15-12-9-7-10-13-16-18(20)21/h6,8,11,14,17,19H,2-5,7,9-10,12-13,15-16H2,1H3,(H,20,21)/b8-6-,14-11+/t17-/m1/s1
• InChI key: NPDSHTNEKLQQIJ-UINYOVNOSA-N

설명

생화학적/생리학적 작용

9(S)-HODE is a pro-inflammatory linoleic acid lipoxygenation product.

9(S)-HODE is produced by the lipoxygenation of linoleic acid. It is a major component of plasma oxidized low-density lipoprotein. 9-HODE has been shown to stimulate cell proliferation and and extracellular matrix synthesis in human mesangial cells via PPARgamma. Pro-inflammatory effects of 9-HODE, acting through the receptor GPR132, can contribute to atherosclerosis progression. 9-HODE has also been shown to activate spinal TRPV1, leading to inflammatory hyperalgesia.

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H319
• 예방조치 성명서: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point (°F): 57.2 °F - closed cup
• Flash Point (°C): 14.0 °C - closed cup