SML0579

EVP4593

≥98% (HPLC)

• 동의어(들): 4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine, N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine, QNZ
• 실험식(Hill 표기법): C₂₂H₂₀N₄O
• CAS Number: 545380-34-5
• Molecular Weight: 356.42
• MDL number: MFCD06411436
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825563
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 15 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: NC1=CC(C(NCCC2=CC=C(OC3=CC=CC=C3)C=C2)=NC=N4)=C4C=C1
• InChI: 1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
• InChI key: IBAKVEUZKHOWNG-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca²⁺) entry (SOC).

EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca²⁺) entry (SOC). It appears that EVP4593 targets heteromeric channels containing TRPC1 as one of the subunits in HD neurons. EVP4593 exhibits neuroprotective effects from glutamate toxicity in nanomolar concentrations.

특징 및 장점

This compound is featured on the Calcium Channels, Cytokine Receptors (Interleukin-1 Receptor/TIR Family) and Cytokine Receptors (Tumor Necrosis Receptor Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

기타 정보

Air sensitive

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable