SML0635

AZD6765 dihydrochloride

≥97% (HPLC)

• 동의어(들): (αS)-α-Phenyl-2-pyridineethanamine dihydrochloride, AR-R 15896 dihydrochloride, FPL 15896 dihydrochloride, Lanicemine dihydrochloride
• 실험식(Hill 표기법): C₁₃H₁₄N₂ · 2HCl
• CAS Number: 153322-06-6
• Molecular Weight: 271.19
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: powder
• 광학 활성: [α]/D +77 to +90°, c = 1 in methanol
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 20 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: [Cl-].[Cl-].[N+H3][C@@H](Cc2[n+H]cccc2)c1ccccc1
• InChI: 1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12;;/h1-9,13H,10,14H2;2*1H/t13-;;/m0../s1
• InChI key: KHJHFYAGQZYCLC-GXKRWWSZSA-N

설명

애플리케이션

AZD6765 dihydrochloride has been used as an antidepressant to improve behavior and metabolic measures in chronic unpredictable mild stress (CUMS).

생화학적/생리학적 작용

AZD6765 is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and fast-acting antidepressant.

AZD6765 is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and fast-acting antidepressant. In a recent study AZD6765 relieved depression within 80 minutes, unlike most antidepressants acting on serotonin or dopamine systems which can take several weeks to work. The effects lasted from about an hour up to 2 weeks. AZD6765 has an IC₅₀ value of 1.3 μM. Unlike more potent drugs such as ketamine, which also has rapid antidepressant activity, AZD6765 has no dissociative side-effects such as hallucinations. Earlier studies inidcated the compound has neuroprotective and anticonvulsant effects.

특징 및 장점

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable