SML0668

Calhex 231 hydrochloride

≥98% (HPLC)

• 동의어(들): 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
• 실험식(Hill 표기법): C₂₅H₂₇ClN₂O · HCl
• CAS Number: 652973-93-8
• Molecular Weight: 443.41
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 15 mg/mL, clear
• 저장 온도: −20°C

설명

애플리케이션

Calhex 231 hydrochloride has been used:

• as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats
• to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs)
• to test its effect on acoustic response bias in zebrafish
• in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 )

생화학적/생리학적 작용

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR.

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC₅₀ of 0.36 μM.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable