SML0724

Bikaverin

from Fusarium subglutinans, ≥98% (HPLC)

• 동의어(들): 6,11-Dihydroxy-3,8-dimethoxy-1-methylbenzo[b]xanthene-7,10, 12-trione, Lycopersin, NSC 215139
• 실험식(Hill 표기법): C₂₀H₁₄O₈
• CAS Number: 33390-21-5
• Molecular Weight: 382.32
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 생물학적 소스: Fusarium subglutinans
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• solubility: DMSO: 0.5 mg/mL (may require sonication and heating); chloroform: 0.5 mg/mL; dichloromethane: 0.5 mg/mL
• 저장 온도: −20°C
• SMILES string: [o]1c2c([c](c4c1cc(cc4C)OC)=O)c(c3c(c2O)C(=O)C(=CC3=O)OC)O
• InChI: 1S/C20H14O8/c1-7-4-8(26-2)5-10-12(7)17(23)15-18(24)13-9(21)6-11(27-3)16(22)14(13)19(25)20(15)28-10/h4-6,24-25H,1-3H3
• InChI key: ZOQMSOSJEWBMHP-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Bikaverin is a red pigment with a polyketide tetracyclic benzoxanthone structure. Bikaverin has an antibiotic activity against some protozoa and fungi and also inhibits Succinate- and NAD-linked respiration in rat mitochondria at 20 mg/mL. At higher concentrations (50 mg/mL) it acts as an oxidative phosphorylation uncoupling agent of tumor cells and isolated rat liver mitochondria. Bikaverin demonstrates antitumor activity on Erlich ascites carcinoma (EAC), leukemia and sarcoma cells.

Bikaverin is a red pigment with a polyketide tetracyclic benzoxanthone structure. Bikaverin has an antibiotic activity against some protozoa and fungi.

재구성

Soluble in DMSO (0.5 mg/mL, may require sonication and heating). For further dilution, water based solutions can be used. Chloroform (0.5 mg/mL) and dichloromethane (0.5 mg/mL).

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable