SML0763

SC144 hydrochloride

≥98% (HPLC)

• 동의어(들): 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide-2-pyrazinecarboxylic acid hydrochloride
• 실험식(Hill 표기법): C₁₆H₁₁FN₆O · HCl
• CAS Number: 917497-70-2
• Molecular Weight: 358.76
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to light brown
• solubility: DMSO: 5 mg/mL, clear (warmed)
• 저장 온도: −20°C
• SMILES string: Fc1cc2c(cc1)[n]3c(ccc3)C(=NNC(=O)c4nccnc4)N2.Cl
• InChI: 1S/C16H11FN6O.ClH/c17-10-3-4-13-11(8-10)20-15(14-2-1-7-23(13)14)21-22-16(24)12-9-18-5-6-19-12;/h1-9H,(H,20,21)(H,22,24);1H
• InChI key: LKFGGXYXFIICED-UHFFFAOYSA-N

설명

애플리케이션

SC144 hydrochloride has been used:

• as a glycoprotein 130 (gp130) inhibitor to evaluate the effect of bazedoxifene on interleukin (IL-6) mediated cell viability in pancreatic cancer cells
• as a gp130 inhibitor to study its effects on signal transducer and activator of transcription 3 (STAT3) activation in mesenchymal precursor cells (KMM) cells
• as an interleukin 6 signal transducer (IL-6ST) inhibitor in media to test its ability to block serum-induced migration/invasion

생화학적/생리학적 작용

SC144 is a potent inhibitor of glycoprotein 130 (gp130).

SC144 is a potent inhibitor of glycoprotein 130 (gp130). SC144 binds to gp130 and blocks STAT3 phosphorylation, nuclear translocation and expression of STAT3 responsive genes. SC144 inhibits the growth of several tumor cell lines, independent of p53 or hormone receptor levels, and inhibits growth of ovarain tumor xenografts in mice.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable