SML0785

AZ628

≥98% (HPLC)

• 동의어(들): 3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-benzamide, AZ-628
• 실험식(Hill 표기법): C₂₇H₂₅N₅O₂
• CAS Number: 878739-06-1
• Molecular Weight: 451.52
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 10 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: [n]1([c](c2c(nc1)ccc(c2)Nc3c(ccc(c3)NC(=O)c4cc(ccc4)C(C)(C)C#N)C)=O)C
• InChI: 1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33)
• InChI key: ZGBGPEDJXCYQPH-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

AZ628 is a potent Raf kinase inhibitor with IC₅₀ values of 105 nM for wild-type B-raf, 34 nM for Raf-B V600E and 29 nM for wild-type c-Raf-1. AZ628 is a type II inhibitor that binds to the catalytically inactive Asp-Phe-Gly (DFG)-out configuration.

AZ628 is a potent Raf kinase inhibitor.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H315,H319,H335
• 예방조치 성명서: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable