SML1315

Ranirestat

≥97% (HPLC)

• 동의어(들): (3R)-2′-[(4-Bromo-2-fluorophenyl)methyl]-spiro[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2′H)-tetrone., AS-3201
• 실험식(Hill 표기법): C₁₇H₁₁BrFN₃O₄
• CAS Number: 147254-64-6
• Molecular Weight: 420.19
• MDL number: MFCD00920915
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825780
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: powder
• 광학 활성: [α]/D -5 to -10°, c = 1.0 in methanol
• 색상: white to beige
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: O=C(N1CC2=C(F)C=C(Br)C=C2)C3=CC=CN3[C@@]4(CC(NC4=O)=O)C1=O
• InChI: 1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1
• InChI key: QCVNMNYRNIMDKV-QGZVFWFLSA-N

설명

생화학적/생리학적 작용

Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor.

Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme in the conversion of D-glucose to fructose via D-sorbitol. Ranirestat has been implicated in diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranirestat prevents sorbitol accumulation and is thus hoped to be effective in the remedy of diabetic neuropathy.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable