SML1596

PPZ2

≥98% (HPLC)

• 동의어(들): 2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-N-(2-ethoxyphenyl)acetamide, 4-(2,3-Dimethylphenyl)-N-(2-ethoxyphenyl)-1-piperazineacetamide
• 실험식(Hill 표기법): C₂₂H₂₉N₃O₂
• CAS Number: 896203-18-2
• Molecular Weight: 367.48
• UNSPSC 코드: 12352200
• NACRES: NA.25

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• 저장 온도: 2-8°C

설명

생화학적/생리학적 작용

PPZ2 is an activator of DAG-activated TRPC3/TRPC6/TRPC7 channels. Neurotrophic.

PPZ2 selectively activates DAG-activated TRPC3/TRPC6/TRPC7 channels. PPZ2 activates native TRPC6-like channels in smooth muscle cells isolated from the rabbit portal vein. PPZ2 induces BDNF-like neurite growth and neuroprotection in cultured neurons.

TRPCs are cation channels, mainly permeable to Ca²⁺ ions. TRPC6 plays a crucial role in tumor development. TRPC3 controls fibronectin expression, thereby regulating wound healing process. TRPC7 is involved in the proliferation of osteoblasts.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable