SML1621
OSMI-1
≥98% (HPLC), powder, OGT inhibitor
동의어(들):
(αR)-α-[[(1,2-Dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide, OSMI 1
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C28H25N3O6S2
CAS Number:
Molecular Weight:
563.64
UNSPSC 코드:
51111800
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Product Name
OSMI-1, ≥98% (HPLC)
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
저장 온도
2-8°C
SMILES string
O=C(N1)C=CC2=C1C=CC(S(N[C@H](C3=C(OC)C=CC=C3)C(N(CC4=CC=CS4)CC5=CC=CO5)=O)(=O)=O)=C2
InChI
1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1
InChI key
IYIGLWQQAMROOF-HHHXNRCGSA-N
관련 카테고리
애플리케이션
OSMI-1 (OGT with a small molecule inhibitor) has been used in proximal ligation assay, Sox2 (SRY (sex determining region Y)-Box 2 ) dual luciferase reporter assay, Sox2 ELISA (enzyme linked immunosorbent assay) and other in vivo approaches, to study the O-Linked β-N-acetylglucosamine (O-GlcNAc) mediated regulation of self-renewal genes in cancer. It has also been used to study the Hippo pathway regulation mediated by O-GlcNAc transferase.
생화학적/생리학적 작용
OGT catalyses the attachment of N-acetylglucosamine moieties to a number proteins during post-translational modification. Inhibition of OGT activity might hinder the rate of viral replication in infections such as Herpes simplex viral disease.
OSMI-1 is a cell permeable inhibitor of OGT (O-GlcNAc transferase).
OSMI-1 is a cell permeable inhibitor of OGT..
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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