SML1791

Urolithin A

≥97% (HPLC), powder, anti-inflammatory

• 동의어(들): 3,8-Dihydroxy-6H-benzo[c]chromen-6-one
• 실험식(Hill 표기법): C₁₃H₈O₄
• CAS Number: 1143-70-0
• Molecular Weight: 228.20
• MDL number: MFCD20275235
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Product Name: Urolithin A, ≥97% (HPLC)
• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1
• InChI: 1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
• InChI key: RIUPLDUFZCXCHM-UHFFFAOYSA-N

설명

애플리케이션

Urolithin A has been used:

• to test its antileukemic activities on leukemic cell lines by in vitro cell proliferation assay
• as a mitophagy activator to study the effect of phosphoglycerate mutase 5 (PGAM5) expression on mitophagic cell death during ischemia-reperfusion (I/R) injury
• to study its inhibitory effect on epithelial-to-mesenchymal transition (EMT) in lung cancer cells via P53-Mdm2-Snail pathway
• to study its effects on streptozotocin-induced diabetic cardiomyopathy in rats by activating sirtuin 1/silent mating type information regulation 2 homolog 1 (SIRT1) signaling

생화학적/생리학적 작용

Urolithin A is a natural product with antiproliferative and antioxidant activity.

Urolithin A is a natural product with antiproliferative and antioxidant activity. Urolithin A is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin A has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer′s Disease.

Urolithin A is the most studied urolithin with anti-inflammatory and anti-obesity properties. It may also prevent the progression of various cancer types including colon, prostate, and bladder cancer by downregulating several oncogenes such as the mammalian target of rapamycin (mTOR) and Kirsten rat sarcoma viral oncogene(K-Ras), upregulating tumor suppressor genes such as p53 and epidermal growth factor receptor (EGFR) in various tumor pathways.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319
• 예방조치 성명서: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable