SML2145

TD52

≥98% (HPLC)

• 동의어(들): N2,N3-bis(3-Ethynylphenyl)-2,3-quinoxalinediamine
• 실험식(Hill 표기법): C₂₄H₁₆N₄
• CAS Number: 1798328-24-1
• Molecular Weight: 360.41
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: C#CC1=CC=CC(NC2=NC3=CC=CC=C3N=C2NC4=CC=CC(C#C)=C4)=C1
• InChI key: SCUPZFSEJFWQIS-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

TD52, an erlotinib analog, is a putative inhibitor of CIP2A that exhibits potent antitumor efficacy on HCC and TNBC cells. TD52 induces apoptosis through downregulation of CIP2A (Cancerous inhibitor of protein phosphatase 2A) in HCC, NSCLC and TNBC cells. Apparently TD52 indirectly downregulates CIP2A transcripts through interrupting the binding of Elk1 to CIP2A promoter. TD52 is a weak inhibitor of EGFR tyrosine kinase.

putative inhibitor of CIP2A that exhibits potent antitumor efficacy on HCC and TNBC cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3