SML2212

RWJ 67657

≥98% (HPLC)

• 동의어(들): 3-Butyn-1-ol, 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl], 4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-Phenylpropyl)-5-(4-Pyridyl)imidazole, 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol, JNJ 3026582
• 실험식(Hill 표기법): C₂₇H₂₄FN₃O
• CAS Number: 215303-72-3
• Molecular Weight: 425.50
• MDL number: MFCD11840606
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: OCCC#CC1=NC(C2=CC=C(F)C=C2)=C(C3=CC=NC=C3)N1CCCC4=CC=CC=C4
• InChI: 1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-18,32H,5-6,9,19-20H2
• InChI key: QSUSKMBNZQHHPA-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

RWJ 67657 is an orally active, potent and selective inhibitor of p38α and p38β MAP kinases. RWJ 67657 inhibits the release of TNF-α and IL-1β from LPS induced blood mononuclear cells. It exhibits cardioprotective and anti-inflammatory activities in vivo.

orally active, potent and selective inhibitor of p38α and p38β MAP kinases

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable