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Merck
모든 사진(1)

주요 문서

SML2333

Sigma-Aldrich

VU0463271

≥98% (HPLC)

동의어(들):

N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide, N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide, N-Cyclopropyl-N-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide

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About This Item

실험식(Hill 표기법):
C19H18N4OS2
CAS Number:
Molecular Weight:
382.50
MDL number:
UNSPSC 코드:
12352200

분석

≥98% (HPLC)

양식

powder

색상

off-white to blue-gray

solubility

DMSO: 2 mg/mL, clear

저장 온도

2-8°C

SMILES string

[s]1c(nc(c1)C)N(C4CC4)C(=O)CSc2nnc(cc2)c3ccccc3

InChI

1S/C19H18N4OS2/c1-13-11-26-19(20-13)23(15-7-8-15)18(24)12-25-17-10-9-16(21-22-17)14-5-3-2-4-6-14/h2-6,9-11,15H,7-8,12H2,1H3

InChI key

DPONSKCACOZTGN-UHFFFAOYSA-N

관련 카테고리

생화학적/생리학적 작용

Potent and selective potassium-chloride cotransporter KCC2 inhibitor with greatly enhanced potency than its structural analogs VU0255011/ML077 & VU0240511.
VU0463271 is a potent and selective potassium-chloride cotransporter 2 (KCC2) inhibitor that displays greatly enhanced potency than its structural analogs VU0255011 (ML077) & VU0240511 (IC50 = 61, 537, and 568 nM, respectively). VU0463271 exhibits much reduced efficacy against the related Na-K-2Cl cotransporter 1 (NKCC1 inhibition max ~37% at 100 μM) and little affinity toward a panel of 68 GPCRs, ion channels, and transporters. Although VU0463271 is reported to exhibit affinity toward mitochondrial translocator protein TSPO (IC50 of 204 nM against PK11195 binding; rat heart) and inhibitory potency against α1B adrenergic receptor (IC50 of 364.7 nM; human α1B CHO transfectants), these proteins are not known to affect chloride homeostasis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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