SML2346

Ganciclovir

≥99% (HPLC), DMSO solution, viral DNA elongation inhibitor

• 동의어(들): Ganciclovir ready made solution, 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, DHPG
• 실험식(Hill 표기법): C₉H₁₃N₅O₄
• CAS Number: 82410-32-0
• Molecular Weight: 255.23
• MDL number: MFCD12197280
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Product Name: Ganciclovir ready made solution, ≥99% (HPLC), 10 mM in DMSO
• 분석: ≥99% (HPLC)
• 양식: DMSO solution
• 농도: 10 mM in DMSO
• 저장 온도: 2-8°C
• SMILES string: [n]1(c2[nH]c(n[c](c2nc1)=O)N)COC(CO)CO
• InChI: 1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
• InChI key: IRSCQMHQWWYFCW-UHFFFAOYSA-N

설명

애플리케이션

Ganciclovir ready-made solution has been used in combination with resveratrol to study its effect on melanoma cells. It has also been used as a synthetic substrate for viral thymidine kinase to study its effects on human-inducible pluripotent stem cells.

생화학적/생리학적 작용

Ganciclovir is a nucleoside guanosine analog that contains an active moiety, ganciclovir triphosphate. This active moiety can inhibit viral replication by interrupting the viral DNA during elongation. Ganciclovir is a potent agent in preventing cytomegalovirus (CMV) retinitis disease in human immunodeficiency virus (HIV) patients. It exhibits therapeutic effects against CMV disease involving the lungs, liver, and gastrointestinal tract. Ganciclovir can be enzymatically phosphorylated to an active triphosphate analog by herpes simplex virus thymidine kinase (HSV-TK) or host-encoded deoxyguanosine kinase. It has the potential to treat allogeneic bone marrow, kidney, heart, liver, and lung transplantations.

기타 정보

Ganciclovir ready made solution in DMSO is provided at 10mM concentration (2.55mg/mL). It is suggested to dilute the provided ready made solution to a working concentration of 2-100μM for cell culture applications.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H340
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point (°F): 188.6 °F - closed cup
• Flash Point (°C): 87 °C - closed cup