SML2346
Ganciclovir
≥99% (HPLC), DMSO solution, viral DNA elongation inhibitor
동의어(들):
Ganciclovir ready made solution, 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, DHPG
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C9H13N5O4
CAS Number:
Molecular Weight:
255.23
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Product Name
Ganciclovir ready made solution, ≥99% (HPLC), 10 mM in DMSO
분석
≥99% (HPLC)
양식
DMSO solution
농도
10 mM in DMSO
저장 온도
2-8°C
SMILES string
[n]1(c2[nH]c(n[c](c2nc1)=O)N)COC(CO)CO
InChI
1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
InChI key
IRSCQMHQWWYFCW-UHFFFAOYSA-N
관련 카테고리
애플리케이션
Ganciclovir ready-made solution has been used in combination with resveratrol to study its effect on melanoma cells. It has also been used as a synthetic substrate for viral thymidine kinase to study its effects on human-inducible pluripotent stem cells.
생화학적/생리학적 작용
Ganciclovir is a nucleoside guanosine analog that contains an active moiety, ganciclovir triphosphate. This active moiety can inhibit viral replication by interrupting the viral DNA during elongation. Ganciclovir is a potent agent in preventing cytomegalovirus (CMV) retinitis disease in human immunodeficiency virus (HIV) patients. It exhibits therapeutic effects against CMV disease involving the lungs, liver, and gastrointestinal tract. Ganciclovir can be enzymatically phosphorylated to an active triphosphate analog by herpes simplex virus thymidine kinase (HSV-TK) or host-encoded deoxyguanosine kinase. It has the potential to treat allogeneic bone marrow, kidney, heart, liver, and lung transplantations.
기타 정보
Ganciclovir ready made solution in DMSO is provided at 10mM concentration (2.55mg/mL). It is suggested to dilute the provided ready made solution to a working concentration of 2-100μM for cell culture applications.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Muta. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
Flash Point (°F)
188.6 °F - closed cup
Flash Point (°C)
87 °C - closed cup
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