SML2522

Diprovocim-1

≥98% (HPLC)

• 동의어(들): (3S,3′S,4S,4′S)-1,1′-(1,4-Phenylenedicarbonyl)bis[N-[(1S,2R)-2-phenylcyclopropyl]-3,4-pyrrolidinedicarboxamide, 3,4-Pyrrolidinedicarboxamide, 1,1′-(1,4-phenylenedicarbonyl)bis[N-[(1S,2R)-2-phenylcyclopropyl]-, (3S,3′S,4S,4′S)-
• 실험식(Hill 표기법): C₅₆H₅₆N₆O₆
• CAS Number: 2170867-89-5
• Molecular Weight: 909.08
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: N7(C[C@H]([C@@H](C7)C(=O)N[C@@H]%10[C@H](C%10)c%11ccccc%11)C(=O)N[C@@H]8[C@H](C8)c9ccccc9)C(=O)c1ccc(cc1)C(=O)N2C[C@H]([C@@H](C2)C(=O)N[C@@H]5[C@H](C5)c6ccccc6)C(=O)N[C@@H]3[C@H](C3)c4ccccc4
• InChI key: ABZBNXFGYUSVCJ-UYMKNZQYSA-N

설명

생화학적/생리학적 작용

Agonist of toll-like receptors TLR2 and TLR1

Diprovocim-1 is a potent agonist of toll-like receptors TLR2 and TLR1 with an EC50 value of 100 pM. Diprovocim-1 was shown to synergize with anti-PD-L1 treatment, inhibiting tumor growth, generating long-term antitumor memory, and curing or prolonging survival of mice engrafted with the murine melanoma B16-OVA.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable