SML2562

Raphin1

≥98% (HPLC)

• 동의어(들): 2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide, N-(2, 3-Dichlorobenzylideneamino) guanidine, Rational inhibitor of a holophosphatase1
• 실험식(Hill 표기법): C₈H₈Cl₂N₄
• CAS Number: 94023-67-3
• Molecular Weight: 231.08
• MDL number: MFCD03653280
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: Clc1c(cccc1\C=N\N=C(N)N)Cl
• InChI: 1S/C8H8Cl2N4/c9-6-3-1-2-5(7(6)10)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+
• InChI key: WLTSTDGGFCQWTK-YIXHJXPBSA-N

설명

생화학적/생리학적 작용

Raphin1 is an orally available, brain penetrant, potent and selective inhibitor of protein phosphatase 1 regulatory subunit 15B (PPP1R15B; R15B). It does not inhibit PP1c. Raphin1 transiently decreases protein synthesis in cells. It is efficacious in mouse model of Huntington′s disease.

orally available, brain penetrant, potent and selective inhibitor of protein phosphatase 1 regulatory subunit 15B (PPP1R15B; R15B).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable