SML2564

PIAA

≥98% (HPLC)

• 동의어(들): (E)-3-(3-phenylbenzo[c]isoxazol-5-yl)acrylic acid, 3-(3-phenyl-2,1-benzisoxazol-5-yl)-2-propenoic acid
• 실험식(Hill 표기법): C₁₆H₁₁NO₃
• CAS Number: 851814-28-3
• Molecular Weight: 265.26
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: n1[o]c(c3c1ccc(c3)\C=C\C(=O)O)c2ccccc2
• InChI: 1S/C16H11NO3/c18-15(19)9-7-11-6-8-14-13(10-11)16(20-17-14)12-4-2-1-3-5-12/h1-10H,(H,18,19)/b9-7+
• InChI key: FCMHXGNYHDXIPU-VQHVLOKHSA-N

설명

생화학적/생리학적 작용

PIAA is an inhibitor of TANK binding kinase 1 (TBK1) and IKB kinase epsilon (IKKε) that has been shown to promote regeneration of pancreatic β-cells. PIAA improved function and replication of mammalian β-cells including primary human β-cells and induced β-cell proliferation in streptozotocin-induced diabetic mice resulting in increased pancreas insulin content and improved glycemic control. PIAA exhibited an IC50 value of 400 nM for TBK1 and 1.07 μM for IKKε with minimum toxicity

TBK1/IKKε inhibitor that promotes regeneration of pancreatic β-cells

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable