SML2609

JH-I-25

≥98% (HPLC)

• 동의어(들): N-[2-Methoxy-4-(4-morpholinyl)phenyl]-6-(1H-pyrazol-3-yl)-2-pyridinecarboxamide
• 실험식(Hill 표기법): C₂₀H₂₁N₅O₃
• CAS Number: 1042673-20-0
• Molecular Weight: 379.41
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: O=C(NC1=C(C=C(C=C1)N2CCOCC2)OC)C3=NC(C4=NNC=C4)=CC=C3
• InChI: 1S/C20H21N5O3/c1-27-19-13-14(25-9-11-28-12-10-25)5-6-17(19)23-20(26)18-4-2-3-15(22-18)16-7-8-21-24-16/h2-8,13H,9-12H2,1H3,(H,21,24)(H,23,26)
• InChI key: RAFFLDOJXQAJPF-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

JH-I-25 is a potent and selective type I inhibitor of IRAK1 and IRAK4 (interleukin-1 receptor–associated kinase 1 and 4). JH-I-25 binds preferentially to the unphosphorylated the ATP-site of the kinase in its active, DFG-in, state.

potent and selective type I inhibitor of IRAK1 and IRAK4

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable