SML2655
Reparixin
≥98% (HPLC)
동의어(들):
αR-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)-benzeneacetamide, (R)-(-)-N-2-[(4-Isobutylphenyl)propionyl]methanesulfonamide, DF 1681Y, Repertaxin
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C14H21NO3S
CAS Number:
Molecular Weight:
283.39
MDL number:
UNSPSC 코드:
51111800
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
powder
광학 활성
[α]/D -80 to -90°, c = 1.0 in ethanol
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
−20°C
SMILES string
[S](=O)(=O)(NC(=O)C(C)c1ccc(cc1)CC(C)C)C
InChI
1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16)
InChI key
KQDRVXQXKZXMHP-UHFFFAOYSA-N
생화학적/생리학적 작용
Noncompetitive allosteric inhibitor of the inflammatory CXCL8 (IL-8) chemokine receptors CXCR1 and CXCR2
Reparixin is a noncompetitive allosteric inhibitor of the inflammatory CXCL8 (IL-8) chemokine receptors CXCR1 and CXCR2 with IC50 values of 1 nM for CXCR1 and 100 nM for CXCR2. It is believed to prevent receptor signaling by locking CXCR1/R2 in an inactive conformation. Reparixin has been studied to prevent ischaemia-reperfusion injury and inflammation and is clinical trials for triple negative breast cancer and to prevent injury occurring after pancreatic islet transplantation.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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