SML2794

Erastin2

≥98% (HPLC)

• 동의어(들): 2-((4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)methyl)-3-(4-isopropoxybiphenyl-3-yl)quinazolin-4(3H)-one, 2-[[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1′-biphenyl]-3-yl]-4(3H)-quinazolinone, 35MEW28
• 실험식(Hill 표기법): C₃₆H₃₅ClN₄O₄
• CAS Number: 1695533-44-8
• Molecular Weight: 623.14
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(N(C1=C(OC(C)C)C=CC(C2=CC=CC=C2)=C1)C(CN3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)=N5)C6=C5C=CC=C6

설명

생화학적/생리학적 작용

Erastin analog with greatly improved system xc- (SLC7A11/xCT + SLC3A2/4F2hc) inhibitory potency and ferropotosis induction efficacy

Erastin2 is an Erastin analog with greatly improved system xc- (SLC7A11/xCT + SLC3A2/4F2hc) inhibitory potency (Erastin2 IC₅₀ = 3.5 nM/CCF-STTG1; Erastin IC₅₀ = 200 nM/HT-1080, 140 nM/Calu-1; Glu release assay) and ferropotosis induction efficacy (HT-1080 EC₅₀ = 150 nM/Erastin2 vs. 1.2 μM/Erastin).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable