SML2978

d9A-2

≥98% (HPLC)

• 동의어(들): N-(14-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-yl)-4′-fluoro-3′-methyl-2-[4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl]-[1,1′-biphenyl]-4-carboxamide
• 실험식(Hill 표기법): C₄₆H₅₄FN₇O₉
• CAS Number: 2690350-15-1
• Molecular Weight: 867.96
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(CCC1N2C(C(C=CC=C3NCCOCCOCCOCCOCCNC(C4=CC(N5CCC(C6=C(C)N=CN6)CC5)=C(C7=CC=C(F)C(C)=C7)C=C4)=O)=C3C2=O)=O)NC1=O
• InChI key: WMBSSRAFHKGIRA-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

d9A-2 is a potent degrader (PROTAC) of the solute carrier SLC9A1 impairs recovery from acid load and is potently cytotoxic to multiple cancer cell lines. Also, d9A-2 incites degradation of some SLC9 members including closely related SLC9A2 and SLC9A4, distant SLC9A7 and SLC9B1. d9A-2 comprise w9A ligand binding to SLC9A1 and the phthalimide-based CRBN binder.

potent degrader (PROTAC) of the solute carrier SLC9A1

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable