SML3002

Sulfuretin

≥98% (HPLC)

• 동의어(들): Sulfuretin, Sulphuretin
• 실험식(Hill 표기법): C₁₅H₁₀O₅
• Molecular Weight: 270.24
• MDL number: MFCD00017304
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 설명: ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 온도: 2-8°C
• SMILES string: OC1=CC=C2C(O/C(C2=O)=C\C3=CC(O)=C(O)C=C3)=C1
• InChI: 1S/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H/b14-6-
• InChI key: RGNXWPVNPFAADO-NSIKDUERSA-N

설명

일반 설명

Sulfuretin is an aurones flavonoid found in the extract of Rhus verniciflua. The Extract of Rhus verniciflua is known in the traditional medicine and scientific community to have anti-cancer properties.Sulfuretin, one of the major constituents of Rhus verniciflua extract was found to have anti-cancer activities via activation of caspase-3 and inhibition of PARP. Moreover, sulfuretin downregulates cyclin D proteins by increasing the expression of miR-30C, a tumor suppressor micro RNA that is studied in regulation of cell proliferation.2 Structure-activity relationships (SAR) of Sulfuretin analogs inhibits the proliferation of leukemia cancer line panel in vitro and in vivo in zebrafish and mice models.Furthermore, Sulfuretin 100mg/Kg in vivo study was beneficial in treating lymphoedema in mice.In addition, Sulfuretin has several other activities such as:

• Sulfuretin is an anti-adipogenic agent, suppressing the adipogenic factors C/EBPα, C/EBPβ and PPARγ, which are crucial regulators at the initial step of adipogenesis.
• Sulfuretin is a potent antioxidant which protects SH-SY5Y cell line from 6-OHDA induced ROS.
• Sulfuretin has antiviral activity through the inhibition of influenza virus neuraminidase in IC50 of 36μM.

생화학적/생리학적 작용

Anti-adipogenic, antineoplastic activity, antioxidative stress, Anti-Inflammatory

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable