SML3098

C-178

≥98% (HPLC)

• 동의어(들): C 178, C178, N-(Dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide, N-3-Dibenzofuranyl-5-nitro-2-furancarboxamide, N-Dibenzofuran-3-yl-5-nitrofuran-2-carboxamide
• 실험식(Hill 표기법): C₁₇H₁₀N₂O₅
• CAS Number: 329198-87-0
• Molecular Weight: 322.27
• MDL number: MFCD01146392
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: faint yellow to dark brown
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC(OC3=C4C=CC=C3)=C4C=C2
• InChI key: URUVDCCYSJEGQQ-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

C-178 is a potent and selective inhibitor against murine, but not human, stimulator of interferon genes (STING) via covalent modifiation of mSTING Cys91. C-178 inhibits mSTING-mediated IFNβ reporter activity (IC50 <500 nM) without affecting RIG-I, and blocks (0.5 μM) downstream TBK1 phosphorylation induction by STING agonist CMA (1.4 h) in mSTING-expressing HEK293T cells.

Potent and selective, Cys91-targeting covalent inhibitor against murine, but not human, STING.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable