SML3308

RyR1-selective inhibitor 1

≥98% (HPLC)

• 동의어(들): 5,8-Dihydro-5-octyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid sodium salt
• 실험식(Hill 표기법): C₁₉H₂₂NO₅·Na
• Molecular Weight: 367.37
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 2 mg/mL, clear (Warmed)
• 저장 온도: room temp

설명

생화학적/생리학적 작용

Potent and selective inhibitor of the type 1 ryanodine receptor (RyR1)

RyR1-selective inhibitor 1 (6,7-(methylenedioxy)-1-octyl-4-quinolone-3-carboxylic acid) potently and selectively inhibits the type 1 ryanodine receptor (RyR1). It prevents and treats malignant hyperthermia and heat stroke in several mouse models. RyR1-selective inhibitor 1 decreases resting intracellular Ca2+, inhibits halothane- and isoflurane-induced Ca2+ release, and suppresses caffeine-induced contracture in skeletal muscle.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable