SML3440
AVN-944
≥98% (HPLC)
동의어(들):
(1R)-1-(Cyanomethyl)propyl N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]carbamate, AVN 944, VX-944, [(1S)-1-[3-[[[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]-carbamic acid (1R)-1-(cyanomethyl)propyl ester
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C25H27N5O5
CAS Number:
Molecular Weight:
477.51
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
-10 to -25°C
SMILES string
N([C@@H](C)c1cc(ccc1)NC(=O)Nc2cc(c(cc2)c3[o]cnc3)OC)C(=O)O[C@H](CC)CC#N
InChI key
GYCPCOJTCINIFZ-OXJNMPFZSA-N
생화학적/생리학적 작용
AVN-944 is an orally bioavailable, highly selective, nonnucleoside and uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with antitumor and antiviral activities. AVN-944 depletes intracellular GMP levels and inhibits DNA and RNA viruses replication via reduction of GTP pools in infected cells. Arrests a wide range of hematologic and epithelial tumor cell types proliferation (IC50 of 0.02 µM to 0.279 µM).
Orally bioavailable, highly selective, nonnucleoside and uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with antitumor and antiviral activities
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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