SML3924

INCB3344

≥98% (HPLC)

• 동의어(들): INCB-3344, INCB 3344, trans-N-(2-{1-[4-(Benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxypyrrolidin-3-ylamino}-2-oxoethyl)-3-(trifluoromethyl)benzamide
• 실험식(Hill 표기법): C₂₉H₃₄F₃N₃O₆
• CAS Number: 1262238-11-8
• Molecular Weight: 577.59
• MDL number: MFCD32264068
• UNSPSC 코드: 51111800
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: -10 to -25°C

설명

생화학적/생리학적 작용

Orally active, potent and selective CCR2 antagonist in vitro and in vivo.
INCB3344 is an orally active, potent and selective CCR2 antagonist (human/mouse/rat/cynomolgus IC50 = 5.1/9.5/7.3/16 nM by competitive binding assays, IC50 = 3.8/7.8/2.7/6.2 nM by chemotaxis assays) with >100-fold selectivity over other homologous chemokine receptors. INCB3344 shows in vivo efficacy in a murine EAE model (thioglycolate-induced peritonitis in mice; 30-100 mg/kg bid. p.o. against peritoneal macrophage influx) and a rat adjuvant arthritis model (100 mg/kg bid. p.o. against adjuvant-induced macrophages infiltration of the joint).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable