SML3945

ARN11391

≥98% (HPLC)

• 동의어(들): 2-Ethyl-N-[2-(oxan-2-ylmethoxy)phenyl]-4,5,6,7-tetrahydroindazole-3-carboxamide, ARN 11391, ARN-11391
• 실험식(Hill 표기법): C₂₂H₂₉N₃O₃
• CAS Number: 1214569-31-9
• Molecular Weight: 383.48
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: -10 to -25°C

설명

생화학적/생리학적 작용

Selective inositol triphosphate receptor type 1 (ITPR1) potentiator for wild-type as well as two ITPR1 SCA29 mutants, R269W or T267M.

ARN11391 is a selective inositol triphosphate receptor type 1 (ITPR1), but not ITPR2 or ITPR3, potentiator (open channel probability (Po) = 0.2 with 20 µM ARN11391 and <0.01 without by on-nucleus nuclear patch-clamp using TPR1-YFP-expressing HEK293 cells) that potenitates IP3- (by photolysis of caged IP3) and UPT-induced calcium increase in HEK293 transfectants expressing wild-type as well as ITPR1 SCA29 mutants, R269W or T267M (5 µM UTP with or without 10 µM ARN11391).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable