SRP0260

PDE2A Active human

recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)

• 동의어(들): CGS-PDE, PED2A4, Phosphodiesterase 2A, cGMP-stimulated phosphodiesterase 4
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in baculovirus infected insect cells
• 분석: ≥70% (SDS-PAGE)
• 양식: aqueous solution
• 특이 활성도: ≥2080 pmol/min-μg
• 분자량: 132 kDa
• 포장: pkg of 5 μg
• 농도: >0.02 mg/mL
• NCBI 수납 번호: NM_002599
• UniProt 수납 번호: O00408
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... PDE2A(5138)

설명

일반 설명

Phosphodiesterase 2A (PDE2A) is encoded by the gene mapped to human chromosome 11q13.4. The encoded protein belongs to the PDE superfamily.[34}

애플리케이션

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

생화학적/생리학적 작용

Phosphodiesterase 2A (PDE2A) plays a vital role in signal transduction. Activated myocardial PDE2 is considered as a potential intracellular antiadrenergic therapeutic method in heart failure (HF). The encoded protein facilitates growth and invasion of the human malignant melanoma PMP cell line. Thus, suppressing PDE2A activity might be considered as a potential method for hindering growth and invasion of malignant tumor cell lines.

단위 정의

One unit is defined as the amount of enzyme that will convert 1 pmole of 3′, 5′-cAMP to 5′ AMP per min at 30°C

물리적 형태

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol and 3 mM DTT.

제조 메모

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.