SRP0400

PRMT4 peptide, biotin

≥90% (HPLC)

• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 분석: ≥90% (HPLC)
• 양식: aqueous solution
• 포장: pkg of 80 nmol
• 농도: 400 μM
• UniProt 수납 번호: Q86X55
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... CARM1(10498)

설명

일반 설명

Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.

애플리케이션

Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications.

생화학적/생리학적 작용

Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.

물리적 형태

Supplied in a TRIS-buffered solution.

기타 정보

200 μL at 400 μM, or 80 nmol. Sold as 80 nmol

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable