SRP2077

p53 (1-363) C-terminal deletion human

recombinant, expressed in insect cells, ≥80% (SDS-PAGE)

• 동의어(들): FLJ92943, LFS1, P53, TRP53
• UNSPSC 코드: 12352200
• NACRES: NA.26

속성

• 생물학적 소스: human
• 재조합: expressed in insect cells
• 분석: ≥80% (SDS-PAGE)
• 양식: frozen liquid
• 분자량: ~41.8 kDa
• 포장: pkg of 5 μg
• 농도: 850 μg/mL
• 색상: clear colorless
• NCBI 수납 번호: NM_000546
• UniProt 수납 번호: P04637
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... TP53(7157)

설명

생화학적/생리학적 작용

Human p53 protein is composed of 393 amino acid residues with several distinct regions. The N-terminal activation domain allows p53 protein to recruit the basal transcription machinery and activate the expression of target genes, whereas the core domain binds to target DNA in a sequence-specific manner and the majority of mutations found in human tumors occur in the region of the gene encoding this domain. The C-terminal domain is composed of predominantly basic residues and modification of the C-terminal basic domain, including acetylation, glycosylation and phosphorylation, is an essential mechanism for regulating p53 function.

물리적 형태

Clear and colorless frozen liquid solution

제조 메모

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable