SRP2132

RAR, γ isoform, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• 동의어(들): NR1B3, RARC
• UNSPSC 코드: 12352202
• NACRES: NA.26

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥70% (SDS-PAGE)
• 양식: frozen liquid
• 분자량: ~77 kDa
• 포장: pkg of 10 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: 800 μg/mL
• 색상: clear colorless
• NCBI 수납 번호: NM_000966
• UniProt 수납 번호: P13631
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... RARG(5916)

설명

생화학적/생리학적 작용

Nuclear receptors form the largest known family of transcription factors and have a crucial role in nearly all aspects of vertebrate development and adult physiology by transducing the effects of hormones into transcriptional responses. The family is defined by two domains: (a) the central, highly conserved, DNA-binding domain (DBD) of approx. 66 amino acids, and (b) the C-terminal, structurally conserved, ligand-binding domain (LBD) of approx. 250 amino acids. The amino-terminal regions are least conserved among nuclear receptor sequences. Retinoids, the natural and syntheic derivatives of vitamin A, have been shown to inhibit the growth of many human tumor cells. Although the exact mechanism for this growth suppression remains unknown, the importance of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) have been established in a number of tumor cell models. Three types of RARs have been identified (RAR, RAR, and RAR ) with homologous but slightly different retinoic acid (RA) binding domains. Transactivation assays and retinoid binding assays with RAR, RAR, and RAR have shown that each RAR has a different affinity for RA and RA analogs.

물리적 형태

Clear and colorless frozen liquid solution

제조 메모

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable